| 摘要 |
A process for synthesis of a labelling reagent, a process for the labelling of a biological molecule, a labelled biological molecule obtained by the process, a process for labelling and fragmentation of a single or double strand nucleic acid, a labelled nucleic acid capable of being obtained by the process, a kit for detection of a target nucleic acid containing a labelled nucleic acid, a solid support onto which is attached a reagent and a process for capture of nucleic acids. |
| 主权项 |
1. A labelling reagent of formula (D):in which:
R1 represents a detectable label or at least two detectable labels linked together by at least one multimeric structure, the detectable label or the at least two detectable labels being independently selected from the group consisting of biotin, fluorophors, fluorescent groups, and luminescent groups, wherein the excitation wavelength of the fluorophors and the fluorescent groups is greater than 450 nm, R2 represents: H, NO2, Cl, Br, F, I, OR, SR, NR2, R, NHCOR, CONHR, or COOR, where R=an alkyl or an aryl group, R4 represents: H, an alkyl group, or an aryl group, and L is a linking arm comprising a linear chain of at least two covalent bonds. |
