| 发明名称 | Immunogenic WT-1 peptides and methods of use thereof | ||
| 摘要 | This invention provides mutated WT1 peptides SGQAYMFPNAPYLPSCLES (SEQ ID No:41) and QAYMFPNAPYLPSCL (SEQ ID No:42), immunogenic compositions and vaccines comprising same, and methods of treating, reducing the incidence of, and inducing immune responses to a WT1-expressing cancer, comprising same. | ||
| 申请公布号 | US9265816(B2) | 申请公布日期 | 2016.02.23 |
| 申请号 | US200712296777 | 申请日期 | 2007.04.10 |
| 申请人 | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH | 发明人 | Scheinberg David A.;May Rena |
| 分类号 | A61K39/00;C07K7/08;C07K14/705;A61K38/10;A61K38/17;C07K14/47 | 主分类号 | A61K39/00 |
| 代理机构 | Pearl Cohen Zedek Latzer Baratz LLP | 代理人 | Cohen Mark S.;Pearl Cohen Zedek Latzer Baratz LLP |
| 主权项 | 1. An isolated, mutated WT1 peptide, comprising: a. a binding motif of a human leukocyte antigen (HLA) class II molecule; and b. a binding motif of an HLA class I molecule, having a point mutation in one or more anchor residues of said binding motif of an HLA class I molecule, wherein said isolated, mutated WT1 peptide is SGQAYMFPNAPYLPSCLES (SEQ ID No: 41) or QAYMFPNAPYLPSCL (SEQ ID No: 42). | ||
| 地址 | New York NY US | ||