| 发明名称 | Methods for modulating D1-D2 dopamine receptor coupling and function | ||
| 摘要 | The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling. | ||
| 申请公布号 | US9266954(B2) | 申请公布日期 | 2016.02.23 |
| 申请号 | US201313862010 | 申请日期 | 2013.04.12 |
| 申请人 | Centre for Addiction and Mental Health | 发明人 | Liu Fang;Pei Lin |
| 分类号 | C07K16/28;C07K14/705;C07K14/47;A61K38/00 | 主分类号 | C07K16/28 |
| 代理机构 | Brooks Kushman P.C. | 代理人 | Brooks Kushman P.C. |
| 主权项 | 1. A method for modulating dopamine (DA) receptor function in a mammal in need of such treatment comprising administering an effective amount of a nucleic acid expressing a polypeptide of up to 140 amino acids and comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3 and comprising SEQ ID NO:2; wherein the polypeptide disrupts D1-D2 coupling in the mammal. | ||
| 地址 | Toronto, Ontario CA | ||