发明名称 |
composição farmacêutica oral, e processo para preparar uma composição |
摘要 |
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system comprising AKT substrate 160 kDa-protein (AS160-protein) with a test substance, and identifying a test substance as a substance altering glucose uptake of a cell by detecting a signal indicative for altered glucose uptake of a cell; a test system comprising a gene coding for the AKT substrate 160 kDa-protein (AS160-protein) and an inducible promoter providing for controllable expression of the gene; the use of the test system for the identification of a substance improving glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell; and the use of AS 160-protein in a model for type 2 diabetes. |
申请公布号 |
BRPI1007161(A2) |
申请公布日期 |
2016.02.23 |
申请号 |
BR2010PI07161 |
申请日期 |
2010.01.27 |
申请人 |
UCB PHARMA SA |
发明人 |
DOMENICO FANARA;MONIQUE BERWAER;SERGE CUYPERS;VALERY BARILLARO |
分类号 |
A61K9/16;A61K9/20;A61K31/4015 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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