Proteases for degrading gluten

摘要

Gluten-degrading proteases derived from insects, including flour beetles, are isolated, and the purified, and recombinant forms can be used to make gluten-containing food safe for patients suffering from gluten intolerance.

主权项

1. A method for treating gluten intolerance in a patient in need of such treatment, wherein said treatment reduces exposure of said patient to immunogenic gluten peptides, said method comprising:
orally administering to said patient a therapeutically effective dose of an isolated, purified or recombinant form of one or more proteases selected from an insect protease comprising a sequence set forth in any one of SEQ ID NO:1, 2, 3, 4, 10, 11, 12, or 13 contemporaneously with the ingestion of a food that may contain gluten.