发明名称 |
Methods and compositions for gene correction |
摘要 |
Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom. |
申请公布号 |
US9267123(B2) |
申请公布日期 |
2016.02.23 |
申请号 |
US201113327558 |
申请日期 |
2011.12.15 |
申请人 |
Sangamo BioSciences, Inc.;Whitehead Institute for Biomedical Research |
发明人 |
Jaenisch Rudolf;Laganiere Josee;Soldner Frank;Zhang Lei |
分类号 |
C12N9/22 |
主分类号 |
C12N9/22 |
代理机构 |
Pasternak Patent Law |
代理人 |
Pasternak Patent Law ;Pasternak Dahna S. |
主权项 |
1. A zinc finger nuclease (ZFN) fusion protein comprising a cleavage domain and a zinc-finger protein (ZFP) that binds to a target site in a leucine rich repeat kinase 2 (LRRK2) or α-synuclein (SCNA) gene in a genome, wherein the ZFP comprises 5 or 6 engineered zinc-finger binding domains, each zinc finger domain comprising a recognition helix region designated F1 to F5 or F1 to F6, wherein the zinc finger protein comprises the recognition helix regions as shown in a single row of Table 2 or Table 4 and further wherein the target site is selected from the group consisting of SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:46, SEQ ID NO:36 and SEQ ID NO:37. |
地址 |
Richmond CA US |