| 主权项 |
1. An anti-ROR1 antibody comprising a combination of all six CDR regions having the following amino acid sequences:
(a) CDRH1, SEQ ID NO: 57; CDRH2, SEQ ID NO: 58; CDRH3, SEQ ID NO: 59, CDRL1, SEQ ID NO: 60; CDRL2, SEQ ID NO: 61; and CDRL3, SEQ ID NO: 62; (b) CDRH1, SEQ ID NO: 63; CDRH2, SEQ ID NO: 64; CDRH3, SEQ ID NO: 65, CDRL1, SEQ ID NO: 66; CDRL2, SEQ ID NO: 67; and CDRL3, SEQ ID NO: 68; (c) CDRH1, SEQ ID NO: 69; CDRH2, SEQ ID NO: 70; CDRH3, SEQ ID NO: 71, CDRL1, SEQ ID NO: 72; CDRL2, SEQ ID NO: 73; and CDRL3, SEQ ID NO: 74; (d) CDRH1, SEQ ID NO: 75; CDRH2, SEQ ID NO: 76; CDRH3, SEQ ID NO: 77, CDRL1, SEQ ID NO: 78; CDRL2, SEQ ID NO: 79; and CDRL3, SEQ ID NO: 80; (e) CDRH1, SEQ ID NO: 81; CDRH2, SEQ ID NO: 82; CDRH3, SEQ ID NO: 83, CDRL1, SEQ ID NO: 84; CDRL2, SEQ ID NO: 85; and CDRL3, SEQ ID NO: 86; (f) CDRH1, SEQ ID NO: 87; CDRH2, SEQ ID NO: 88; CDRH3, SEQ ID NO: 89, CDRL1, SEQ ID NO: 90; CDRL2, SEQ ID NO: 91; and CDRL3, SEQ ID NO: 92; (g) CDRH1, SEQ ID NO: 93; CDRH2, SEQ ID NO: 94; CDRH3, SEQ ID NO: 95, CDRL1, SEQ ID NO: 96; CDRL2, SEQ ID NO: 97; and CDRL3, SEQ ID NO: 98; (h) CDRH1, SEQ ID NO: 99; CDRH2, SEQ ID NO: 100; CDRH3, SEQ ID NO: 101, CDRL1, SEQ ID NO: 102; CDRL2, SEQ ID NO: 103; and CDRL3, SEQ ID NO: 104; (i) CDRH1, SEQ ID NO: 105; CDRH2, SEQ ID NO: 106; CDRH3, SEQ ID NO: 107, CDRL1, SEQ ID NO: 108; CDRL2, SEQ ID NO: 109; and CDRL3, SEQ ID NO: 110; (j) CDRH1, SEQ ID NO: 111; CDRH2, SEQ ID NO: 112; CDRH3, SEQ ID NO: 113, CDRL1, SEQ ID NO: 114; CDRL2, SEQ ID NO: 115; and CDRL3, SEQ ID NO: 116; (k) CDRH1, SEQ ID NO: 117; CDRH2, SEQ ID NO: 118; CDRH3, SEQ ID NO: 119, CDRL1, SEQ ID NO: 120; CDRL2, SEQ ID NO: 121; and CDRL3, SEQ ID NO: 122; (l) CDRH1, SEQ ID NO: 123; CDRH2, SEQ ID NO: 124; CDRH3, SEQ ID NO: 125, CDRL1, SEQ ID NO: 126; CDRL2, SEQ ID NO: 127; and CDRL3, SEQ ID NO: 128; or (m) CDRH1, SEQ ID NO: 129; CDRH2, SEQ ID NO: 130; CDRH3, SEQ ID NO: 131, CDRL1, SEQ ID NO: 132; CDRL2, SEQ ID NO: 133; and CDRL3, SEQ ID NO: 134. |
