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1. A heterocyclic compound of the general formulae IA or IB a stereoisomer, N-oxide, tautomer and/or physiologically tolerated acid addition salt thereof; or a compound of the general formulae IA or IB, wherein at least one of the atoms has been replaced by its stable, non-radioactive isotope, wherein X1, X2, X3 and X4 are independently of each other selected from the group consisting of CR1 and N; each R1 is independently selected from the group consisting of hydrogen, cyano, NRaRb, OH, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, COOH, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, C1-C6-alkyl-NRaRb, CO—NRaRb, an aromatic radical Ar, which is selected from the group consisting of phenyl and a 5- or 6-membered N- or C-bound heteroaromatic radical containing 1, 2 or 3 heteroatoms independently selected from the group consisting of O, S and N as ring members, wherein Ar is unsubstituted or carries one or two radicals R7 and wherein Ar may also be bonded via a CH2 group, and a saturated or partially unsaturated 3-, 4-, 5-, 6- or 7-membered heterocyclic radical containing 1, 2 or 3 heteroatoms selected from the group consisting of O, S and N as ring members, wherein the heterocyclic radical is unsubstituted or substituted by 1, 2, 3 or 4 radicals independently selected from the group consisting of halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; R2 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, OH or F; R3 and R4 form together a bridging group —(CH2)m—, wherein m is 3, 4 or 5, where 1, 2 or 3 of the CH2 groups may be replaced by a group or a heteroatom selected from the group consisting of CO, O, S, SO, SO2, NRc and NO, and where 1, 2 or 3 hydrogen atoms of the bridging group may be replaced by a radical R8; R5 and R6 are independently selected from the group consisting of hydrogen, halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy and NRaRb; each R7 is independently selected from the group consisting of halogen, OH, CN, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, NRaRb, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, CO—NRaRb, a phenyl group, and a saturated, partially unsaturated or aromatic 5- or 6-membered heterocyclic radical containing 1, 2 or 3 heteroatoms selected from the group consisting of O, S and N as ring members, wherein phenyl and the hetero-cyclic radical are, independently of each other, unsubstituted or substituted by 1, 2, 3 or 4 radicals independently selected from the group consisting of halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy, or in the hetero-cyclic ring two geminally bound radicals may together form a group═O; each R8 is independently selected from the group consisting of halogen, OH, CN, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, NRaRb, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, CO—NRaRb, a phenyl group and a saturated, partially unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered heterocyclic radical containing 1, 2 or 3 heteroatoms selected from the group consisting of O, S and N as ring members, wherein phenyl and the heterocyclic radical are, independently of each other, unsubstituted or substituted by 1, 2, 3 or 4 radicals independently selected from the group consisting of halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; Ra and Rb are independently of each other selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylcarbonyl, C1-C4-haloalkylcarbonyl, C1-C6-alkoxycarbonyl and C1-C6-haloalkoxycarbonyl; or
Ra and Rb form, together with the nitrogen atom to which they are bonded, a 3-, 4-, 5-, 6- or 7-membered saturated or unsaturated aromatic or non-aromatic N-heterocyclic ring, which may contain 1 further heteroatom or heteroatom-containing group selected from the group consisting of N, O, S, SO and SO2 as a ring member, where the N-heterocyclic ring may carry 1 or 2 radicals selected from the group consisting of halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; and each Rc is independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylcarbonyl, C1-C4-haloalkylcarbonyl, C1-C6-alkoxycarbonyl and C1-C6-haloalkoxycarbonyl. |
