| 发明名称 |
Anti-PDGFR-beta antibodies and uses thereof |
| 摘要 |
The present invention provides antibodies that bind to platelet derived growth factor receptor beta (PDGFR-beta) and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PDGFR-beta with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders associated with PDGFR-beta signaling and/or PDGFR-beta cellular expression, such as ocular diseases, fibrotic diseases, vascular diseases and cancer. |
| 申请公布号 |
US9265827(B2) |
申请公布日期 |
2016.02.23 |
| 申请号 |
US201414148753 |
申请日期 |
2014.01.07 |
| 申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
Wiegand Stanley J.;Lobov Ivan B. |
| 分类号 |
A61K39/395;A61K39/00;C07K16/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
DiGabriele Petti Anna D.;Cottingham Frank;Bozicevic Karl |
| 主权项 |
1. An isolated antibody or antigen-binding fragment thereof that specifically binds human platelet derived growth factor receptor beta (PDGFR-beta), wherein the antibody or antigen-binding fragment thereof comprises three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) comprising SEQ ID NOs: 132, 134 and 136, respectively; and three light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3) comprising SEQ ID NOs: 140, 142 and 144, respectively. |
| 地址 |
Tarrytown NY US |
