Method and apparatus for controlling cardiac therapy based on electromechanical timing

摘要

Devices and methods for therapy control based on electromechanical timing involve detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.

主权项

1. A method of treating dyssynchrony of a patient's heart, comprising:
detecting electrical depolarization of a patient's ventricular tissue; detecting mechanical cardiac activity of the ventricular tissue resulting from the electrical depolarization; determining a timing relationship between the detected electrical depolarization and the detected mechanical cardiac activity; and controlling a therapy delivered to the patient based on the timing relationship to treat at least one of intraventricular dyssynchrony and dyssynchrony between the left and right ventricles, wherein at least one of the steps of determining and controlling is implemented at least in part by a circuit.