发明名称 |
AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS |
摘要 |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment. |
申请公布号 |
CA2647545(C) |
申请公布日期 |
2016.02.23 |
申请号 |
CA20072647545 |
申请日期 |
2007.04.02 |
申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
BOUERES, JULIA KAY;BRANCA, DANILA;FERRIGNO, FEDERICA;JONES, PHILIP;MURAGLIA, ESTER;ONTORIA ONTORIA, JESUS MARIA;ORVIETO, FEDERICA;SCARPELLI, RITA;SCHULTZ-FADEMRECHT, CARSTEN |
分类号 |
C07D231/56;A61K31/395;A61K31/416;A61K31/4192;A61K31/4439;A61K31/454;A61K31/496;A61K31/5377;A61K31/551;A61P35/00;C07D249/18;C07D249/20;C07D401/02;C07D403/02 |
主分类号 |
C07D231/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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