Compositions and methods for preventing or treating <i>Burkholderia </i>infection

摘要

The present invention provides a protein or a fragment or a variant of said protein, wherein the protein, fragment, or variant is capable of producing a protective immune response in an animal, wherein the immune response is protective against infection by Burkholderia species. Also provided is a method of preventing or treating infection in an animal caused by Burkholderia species which comprises administering an effective amount of the pharmaceutical composition of the present invention to the animal infected with Burkholderia species.

主权项

1. A method of inducing a protective or therapeutic immune response to Burkholderia mallei or B. pseudomallei in an animal comprising administering a pharmaceutical composition comprising at least one isolated protein comprising the amino acid sequence of SEQ ID NO:1or SEQ ID NO:2 and an adjuvant to the animal, wherein an immune response to Burkholderia mallei or B. pseudomallei is induced.