| 发明名称 | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs | ||
| 摘要 | Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | ||
| 申请公布号 | US9267138(B2) | 申请公布日期 | 2016.02.23 |
| 申请号 | US201514705580 | 申请日期 | 2015.05.06 |
| 申请人 | Regulus Therapeutics Inc. | 发明人 | Bennett C. Frank;Freier Susan M.;Griffey Richard H. |
| 分类号 | C12N15/113 | 主分类号 | C12N15/113 |
| 代理机构 | McNeill Baur PLLC | 代理人 | McNeill Baur PLLC |
| 主权项 | 1. A method of inhibiting the activity, function, or amount of miR-103 (SEQ ID NO: 225) and/or miR-107 (SEQ ID NO: 229), comprising contacting a cell with a compound comprising a modified oligonucleotide, wherein: the modified oligonucleotide consists of 8, 9, 10, 11, or 12 linked monomeric subunits; each monomeric subunit of the modified oligonucleotide comprises a modified sugar moiety; and the modified oligonucleotide is complementary to miR-103 and/or miR-107 with no more than one mismatch. | ||
| 地址 | San Diego CA US | ||