Methods of treating neuroendocrine tumors using frizzled-binding agents

摘要

Novel methods of treating neuroendocrine tumors are provided. In one embodiment, the method comprises administering to a subject in need thereof a therapeutically effective dose of a Wnt antagonist. In one embodiment, the Wnt antagonist is an anti-FZD antibody. In another embodiment, the Wnt antagonist is a soluble FZD receptor polypeptide. In a further embodiment, the Wnt antagonist is an anti-Wnt antibody.

主权项

1. A method of treating neuroendocrine cancer, wherein the method comprises administering to a subject in need thereof a therapeutically effective amount of an anti-frizzled (FZD) receptor antibody that specifically binds two or more human FZD receptors selected from the group consisting of: FZD1, FZD2, FZD5, FZD7, and FZD8, wherein the neuroendocrine cancer is resistant to treatment with one or more of a chemotherapeutic, a somatostatin analog and a kinase inhibitor.