| 发明名称 | Apolipoprotein AIV as an antidiabetic peptide | ||
| 摘要 | Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. The pharmaceutical composition includes apolipoprotein A-IV formulated for administration to a subject for the treatment of type two diabetes mellitus. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof. | ||
| 申请公布号 | US9266941(B2) | 申请公布日期 | 2016.02.23 |
| 申请号 | US201514704418 | 申请日期 | 2015.05.05 |
| 申请人 | University of Cincinnati | 发明人 | Tso Patrick;Davidson Sean;Woods Stephen;Wang Fei |
| 分类号 | C07K1/00;C07K14/00;C07K16/00;C07K17/00;C09H1/04;A61K38/14;A61K38/16;C07K14/775;A61K38/00;A61K38/28;A61K38/22;A61K39/00;C07K14/47;A61K38/17;C07K14/655;C07K14/605;C07K9/00;A61K38/26 | 主分类号 | C07K1/00 |
| 代理机构 | McCarter & English, LLP | 代理人 | McCarter & English, LLP ;Davis Steven G.;Bai Mei |
| 主权项 | 1. A polypeptide, wherein the amino acid sequence of the polypeptide is:(SEQ ID NO. 4) X1EVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADX2LKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKX3LSLPELEQQQEQX4QEQQQEQVQMLAPLES wherein, X1 is G, A or V; X2 is E or K; X3 is T or S; and X4 is Q or H, optionally the polypeptide is glycosylated. | ||
| 地址 | Cincinnati OH US | ||