Peptides for inducing heterosubtypic influenza T cell responses

摘要

The present invention provides compositions and methods for generation of an anti-influenza immune response. In particular, conserved T cell epitopes within matrix protein and nucleoprotein components of influenza virus have been identified and further screened for those structures that will bind either or both of HLA I and II molecules. Methods for vaccinating subjects with formulations of such peptides for the treatment or prevention of influenza infaction also are described.

主权项

1. A method of inducing an anti-influenza immune response in a subject comprising administering to a subject a first influenza peptide and a second influenza peptide each being 9-15 residues in length, wherein said first and second peptides are SEQ ID NO: 3 and 43.