Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders

摘要

Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and/or to stabilize β-catenin and formulations thereof. Some aspects of this invention relate to compositions comprising such compounds. Some aspects of the invention provide methods of using such compounds and/or compositions in the treatment of subjects having a neurological disease and/or psychiatric disorder. Some aspects of this invention provide methods of using ruboxistaurin, enzastaurin, sunitinib, midostaurin, lestaurtinib, 7-hydroxystaurosporine, and/or Chir99021 in the treatment of subjects having a neurological disease and/or psychiatric disorder. In some embodiments, compounds are administered in combination with Lithium.

主权项

1. A method for treating bipolar disorder in a subject, comprising administering ruboxistaurin, or a pharmaceutically acceptable salt thereof, to the subject in an effective amount to treat the bipolar disorder based on said subject being indicated or diagnosed to have bipolar disorder, wherein the subject is non-responsive to lithium.