METHOD FOR PREPARING OF α-SILYLAMINES FROM α-SILYLMETHYL AZIDES

摘要

The present invention relates to a method of preparing α-silylamine compounds and, more particularly, to a one-pot method of preparing various α-silylamine compounds which uses an α-silyl methyl azide compound as a starting material under a moderate condition and a metal complex compound catalyst and passes through an α-silylamine without a substituent on nitrogen thereof as an intermediate product, and makes a reaction with various allyl borate compounds. In the present invention, α-silylamine compounds having multiple sterocenters and functional groups comprising high diastereoselectivity, enantioselectivity, and a double-bond geometry can be manufactured through a one-pot method.