| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound having a dual PI3K and mTOR inhibition, a good activity, a high selectivity, and good pharmacokinetic characteristics.SOLUTION: The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its pharmaceutically acceptable salt, stereoisomer and deuteride thereof, in which R, R, R, R, R, R, Rand X are as defined in the specification; the present invention also relates to a method for preparing the compound, a pharmaceutical composition and a pharmaceutical formulation containing the compound, and use of the compound in treating and/or preventing a proliferative disease and in the manufacture of a medicament for treating and/or preventing a proliferative disease.SELECTED DRAWING: None |
