发明名称 |
QUINOLINE DERIVATIVES USEFUL AS UBIQUITINATION INHIBITORS |
摘要 |
Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure. Formule (I) and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, R2, R3 and R4 are as described herein. In certain embodiments, a compound disclosed herein inhibits ubiquitination, and can be used to treat disease by blocking the degradation of tumor suppressors. |
申请公布号 |
WO2016025779(A1) |
申请公布日期 |
2016.02.18 |
申请号 |
WO2015US45174 |
申请日期 |
2015.08.14 |
申请人 |
RIGEL PHARMACEUTICALS, INC. |
发明人 |
CARROLL, DAVID;SRAN, ARVINDER;SINGH, RAJINDER;HUANG, JIANING;TSVETKOV, LYUBEN;ISSAKANI, SARKIZ;PAYAN, DONALD;SHAW, SIMON |
分类号 |
C07D401/14;A61K31/4706;A61K31/496;A61K31/5377;A61P35/00;C07D215/40;C07D401/04;C07D401/12;C07D405/04;C07D409/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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