摘要 |
The present disclosure provides compounds of any one of Formulae (A) to (L). The present disclosure also provides compositions, uses, and methods that include or involve a compound described herein, a serine/threonine-protein kinase B-Raf (BRAF) inhibitor, an epidermal growth factor receptor (EGFR) inhibitor, a vascular endothelial growth factor 1 (VEGFR1) inhibitor, a fibroblast growth factor receptor 1 (FGFR1) inhibitor, or a combination thereof. The compounds, compositions, uses, and methods are useful in changing the pluripotency state of a vertebrate cell to a more naive state. |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
THEUNISSEN, THOROLD, W.;GRAY, NATHANAEL;JAENISCH, RUDOLF |