发明名称 |
MODIFIED IL-2 VARIANTS THAT SELECTIVELY ACTIVATE REGULATORY T CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
摘要 |
The invention described herein is a novel IL-2 protein with selective agonist activity for Regulatory T cells and with an additional amino acid substitution that enable chemical conjugation with Polyethyene Glycol (PEG) that increase circulating half-life compared to the IL-2 selective agonist alone. A preferred IL-2 selective agonist variant is IL2/N88R/C125S/D109C. |
申请公布号 |
WO2016025385(A1) |
申请公布日期 |
2016.02.18 |
申请号 |
WO2015US44462 |
申请日期 |
2015.08.10 |
申请人 |
DELINIA, INC. |
发明人 |
GREVE, JEFFREY |
分类号 |
A61K38/20;C07K14/55;C07K17/08 |
主分类号 |
A61K38/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|