发明名称 |
THERAPY SELECTION FOR PSORIASIS AND PSORIATIC ARTHRITIS |
摘要 |
The present invention provides methods for selecting an individual with psoriasis (Ps) or psoriatic arthritis (PsA) who should receive or who is likely to respond to a treatment with an anti-tumor necrosis factor alpha (anti-TNFα) therapy. In addition, provided herein are methods for selecting an individual with Ps or PsA who should receive or who is likely to respond to a therapy that is not an anti-TNFα therapy, e.g., a non-anti-TNFα therapy for the treatment of Ps or PsA. Specifically, the methods of the present invention relate to detecting the presence of distinct alleles of the PDE3A-SLCO1C1 locus which are associated with a clinical response to an anti-TNFα therapy or a non-anti-TNF therapy in patients with Ps or PsA. |
申请公布号 |
WO2016024254(A1) |
申请公布日期 |
2016.02.18 |
申请号 |
WO2015IB56212 |
申请日期 |
2015.08.14 |
申请人 |
FUNDACIÓ HOSPITAL UNIVERSITARI VALL D’HEBRON-INSTITUT DE RECERCA;HOSPITAL CLINIC DE BARCELONA;FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL |
发明人 |
BARRIL, SARA MARSAL;CANO, ANTONIO JULIÀ;DE DIOS CAÑETE CRESPILLO, JUAN;FERRÁNDIZ FORASTER, CARLES |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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