发明名称 |
NOVEL POTASSIUM CHANNEL BLOCKERS AND USE THEREOF IN THE TREATMENT OF AUTOIMMUNE DISEASES |
摘要 |
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X-4 is D, E or other negatively-charged amino acid or derivative thereof, X-3 is E, I, L, S, V, W or a tryptophan derivative, X-2 is any amino acid, X-1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety. |
申请公布号 |
WO2016023072(A1) |
申请公布日期 |
2016.02.18 |
申请号 |
WO2015AU00487 |
申请日期 |
2015.08.14 |
申请人 |
MONASH UNIVERSITY;LA TROBE UNIVERSITY;PEPTIDES INTERNATIONAL, INC.;BAYLOR COLLEGE OF MEDICINE |
发明人 |
NORTON, RAYMOND, S;CHANG, SHIH, CHIEH;PENNINGTON, MICHAEL, W;BEETON, CHRISTINE;SMITH, BRIAN, J. |
分类号 |
C07K19/00;A61K38/17;A61P35/00;A61P37/00;C07K4/00;C07K14/46;C12N15/63 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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