主权项 |
1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein:
A is aryl or heteroaryl, wherein the aryl or heteroaryl is optionally substituted, and the aryl or heteroaryl is optionally fused to an optionally substituted carbocyclyl or an optionally substituted heterocyclyl; X is selected from —NH—S(O)2—, —S(O)2—NH—, —NH—S(O)2—CH2—, —CH2—S(O)—NH—, —NH—S(O)—CH2—, —NH—S(O)—, —S(O)—NH—, or —CH2—S(O)2—NH—; Y is C(H) or N; provided that no more than two Y groups are N; R1a is hydroxyl, —CH2OH, —CHO, —CO2H, —N(R10a)2, —CO2—C1-6 alkyl, —OP(═O)(OH)2, or —OCO2—CH2—OP(═O)(OH)2; R1b is C1-8 alkyl optionally substituted with one to four R5 groups; C1-8 alkenyl optionally substituted with one to four R5 groups; cycloalkyl; heterocycle; aryl; heteroaryl; cycloalkylalkyl; cycloalkylalkenyl; heterocyclylalkyl; heterocyclylalkenyl; aralkyl; aralkenyl; heteroaralkyl; heteroaralkenyl; or —OH, with the proviso that when R1a is OH, R1b is not OH; wherein each cycloalkyl, heterocycle, aryl, heteroaryl, cycloalkylalkyl, cycloalkylalkenyl, heterocyclylalkyl, heterocyclylalkenyl, aralkyl, aralkenyl, heteroaralkyl, or heteroaralkenyl is optionally substituted; each R2 is independently selected from halo, alkyl, CN, OH, and alkoxy, wherein said alkyl or alkoxy is optionally substituted with one to four R5 groups; or two adjacent R2 groups are taken together with the ring atoms they are attached to form a 5- or 6-membered carbocyclic, aryl, heterocyclic or heteroaryl ring; each R4 is independently selected from halo, alkyl, alkoxy, haloalkyl, haloalkoxy and hydroxyl; each R5 is independently selected from halo, OH, C1-6 alkoxy, CN, NH2, —SO2—C1-6 alkyl, —NH(C1-6 alkyl), and —N(C1-6 alkyl)2; each R10a is independently selected from hydrogen or C1-6 alkyl; n is 0, 1, 2 or 3; and m is 0, 1 or 2; provided that a compound of Formula (I) is not the following: (1) 4-[[4-hydroxy-4-(4-methylphenyl)-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (2) 4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (3) 4-[[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (4) 4-[[4-(2-fluoro-5-methylphenyl)-4-hydroxy-1-piperidinyl]carbonyl]-N-2-thiazolyl-benzenesulfonamide; (5) 4-phenyl-1-[4-[(phenylamino)sulfonyl]benzoyl]-4-piperidinecarboxylic acid methyl ester; (6) 1-[4-[[(2-methylphenyl)amino]sulfonyl]benzoyl]-4-phenyl-4-piperidinecarboxylic acid methyl ester; or (7) N-(4-fluorophenyl)-4-[[4-hydroxy-4-(methoxymethyl)-1-piperidinyl]carbonyl]-benzenesulfonamide. |