| 发明名称 |
Polysialic acid and use for treatment of neurodegenerative and neuroinflammatory diseases |
| 摘要 |
The present invention relates to a branched or unbranched free or glycosidically bound polysialic acid according to general formula (1) as given as follows poly-(α(2→8 or 2→9)Neu5Ac)n (1) wherein Neu5Ac is N-acetylneuraminic acid, and n is an integer in the range from 14 to 26 and/or pharmaceutically acceptable salts thereof, a polysaccharide composition comprising the polysialic acid (1), and the use as a medicament, particularly in the therapeutic and/or prophylactic treatment of degenerative, demyelinating and inflammatory diseases of the central nervous system, and degenerative or inflammatory retinal diseases. |
| 申请公布号 |
US2016046734(A1) |
申请公布日期 |
2016.02.18 |
| 申请号 |
US201414779800 |
申请日期 |
2014.03.18 |
| 申请人 |
RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN ;UNIVERSITÄT ZU KÖLN |
发明人 |
NEUMANN Harald;KOPATZ Jens;Shahraz Anahita;KARLSTETTER Marcus;LANGMANN Thomas |
| 分类号 |
C08B37/00 |
主分类号 |
C08B37/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A branched or unbranched free or glycosidically bound polysialic acid according to general formula (1) as given as follows and/or pharmaceutically acceptable salts thereof:
poly-(α(2→8 or 2→9)Neu5Ac)n (1) wherein: Neu5Ac is N-acetylneuraminic acid, and n is an integer in the range from 14 to 26. |
| 地址 |
Bonn DE |
