| 摘要 |
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/138556 Al 19 September 2013 (19.09.2013) W I P 0 I P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K31/4985 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/US2013/03 1202 DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 14 March 2013 (14.03.2013) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 61/611,370 15 March 2012 (15.03.2012) US 61/715,329 18 October 2012 (18.10.2012) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: SIGNAL PHARMACEUTICALS, LLC GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, [US/US]; 10300 Campus Point Drive, Suite 100, San UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Diego, CA 92121 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: XU, Shuichan; 9650 Deer Trail Place, San EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Diego, CA 92127 (US). HEGE, Kristen, Mae; 616 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Howard Ave., Burlingame, CA 94010 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). (74) Agents: INSOGNA, Anthony, M. et al.; Jones Day, 222 Published: East 41st Street, New York, NY 10017-6702 (US). - with international search report (Art. 21(3)) (54) Title: TREATMENT OF CANCER WITH TOR KINASE INHIBITORS (57) Abstract: Provided herein are methods for treating or preventing ETS overexpressing Ewings sarcoma, comprising administer ing an effective amount of a TOR kinase inhibitor to a patient having ETS overexpressing Ewings sarcoma. |
