Foot and Mouth Disease Virus (FMDV) Consensus Proteins, Coding Sequences Therefor and Vaccines Made Therefrom

摘要

The present invention relates to synthetic, consensus foot-and-mouth disease virus (FMDV) immunogenic proteins and nucleic acid molecule encoding such proteins, to vaccines against FMDV, to methods for inducing immune responses against FMVD, to methods for distinguishing between individuals infected with FMDV versus those vaccinated against FMDV, and methods of prophylactically and/or therapeutically immunizing individuals against FMDV.

主权项

1. A nucleic acid molecule comprising sequences encoding one or more sequences selected from the group consisting of:
a) a leader sequence linked to coding sequence for viral protein VP4 linked at its C terminus to coding sequence for a protease cleavage site linked at its C terminus to coding sequence for viral protein VP2 linked at its C terminus to coding sequence for a protease cleavage site linked at its C terminus to coding sequence for viral protein VP3 linked at its C terminus to coding sequence for a protease cleavage site linked to coding sequence for viral protein VP1 linked at its C terminus to coding sequence for a protease cleavage site linked to coding sequence for viral protein 2A; b) a leader sequence linked to coding sequence for viral protein VP2 linked at its C terminus to coding sequence for a protease cleavage site linked at its C terminus to coding sequence for viral protein VP3 linked at its C terminus to coding sequence for a protease cleavage site linked to coding sequence for viral protein VP1 linked at its C terminus to coding sequence for a protease cleavage site linked to coding sequence for viral protein 2A; c) a leader sequence linked to coding sequence for viral protein VP4 linked at its C terminus to coding sequence for a protease cleavage site linked at its C terminus to coding sequence for viral protein VP2 linked at its C terminus to coding sequence for a protease cleavage site linked at its C terminus to coding sequence for viral protein VP3 linked at its C terminus to coding sequence for a protease cleavage site linked to coding sequence for viral protein VP1; and d) a leader sequence linked to coding sequence for viral protein VP2 linked at its C terminus to coding sequence for a protease cleavage site linked at its C terminus to coding sequence for viral protein VP3 linked at its C terminus to coding sequence for a protease cleavage site linked to coding sequence for viral protein VP1.