| 发明名称 |
Attenuated Bordetella Strains |
| 摘要 |
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided. |
| 申请公布号 |
US2016045587(A1) |
申请公布日期 |
2016.02.18 |
| 申请号 |
US201514860210 |
申请日期 |
2015.09.21 |
| 申请人 |
Institut Pasteur de Lille ;Institut National de la Sante et de la Recherche Medicale (INSERM) |
发明人 |
LOCHT Camille;Mielcarek Nathalie;Debrie Anne-Sophie;Raze Dominique;Bertout Julie |
| 分类号 |
A61K39/02 |
主分类号 |
A61K39/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A live attenuated Bordetella pertussis strain comprising at least a mutated pertussis toxin (ptx) gene, a deleted or mutated dermonecrotic (dnt) gene, and a heterologous ampG gene replacing the Bordetella ampG gene, wherein the strain is able to colonize and induce protective immunity against Bordetella pertussis infection in a subject when administered to the subject. |
| 地址 |
Lille Cedex FR |
