N-Haloalkylindoline Intermediates, Their Process And Use In Preparation of Silodosin And its Derivatives

摘要

The present invention provides novel indoline compounds, derivatives of Formula 1 and salts thereof; which can be effectively used for the preparation of a1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts.;

主权项

1. Compounds of Formula 1 and salts thereof; wherein:
R1 is selected from hydrogen and C1-C4 alkyl;R2 is nitro or NR4R5, wherein, R4 and R5 are independently selected from the group comprising of hydrogen, C1-C4 alkyl, and substituted C1-C4 alkyl;R1 and R2 are optionally absent;X is halogen;n is an integer of 1 to 6;R3 is selected from the group comprising of hydrogen, formyl, cyano, oxime O-methyl oxime, O-acetyl oxime, O-propanoyl oxime, O-butanoyl oxime, and amide optionally substituted with aryl, C1-C4 alkyl or C1-C4 cycloalkyl;A(B) are linked either by single or double bond, wherein A is —CH2 or —CH and B is selected from the group comprising of —CH2, —CH, —O, —OH, and —COR, wherein R is hydrogen, C1-C4 alkyl, C1-C4 alkoxy or hydroxyl.