PRODUCTION OF FULLY PROCESSED AND FUNCTIONAL FACTOR X IN A FURIN-SECRETING MAMMALIAN EXPRESSION SYSTEM

摘要

Disclosed herein are methods for production of fully-processed mature Factor X in an expression system producing a controlled amount of furin between 50 U/mL and 300 U/mL of culture supernatant. Also disclosed are transformed cells, expression systems, and expression vectors for the expression of furin and Factor X.