发明名称 |
PREVENTION OF TUMOUR METASTASIS BY INHIBITION OF NECROPTOSIS |
摘要 |
The present invention relates to an inhibitor of necroptosis for use in preventing the metastasis of tumours. Further, the present invention relates to a method of preventing the metastasis of tumours by inhibiting necroptosis and to a method for modulating the transmigration of metastasising tumour cells through endothelium by modulating necroptosis as well as to an in-vitro method of identifying an inhibitor of necroptosis suitable as a lead compound and/or as a medicament for the prevention of tumour metastasis. Moreover, the present invention also relates to a method of identifying necroptotic and necrotic cells. |
申请公布号 |
WO2016023918(A1) |
申请公布日期 |
2016.02.18 |
申请号 |
WO2015EP68495 |
申请日期 |
2015.08.11 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
OFFERMANNS, STEFAN;STRILIC, BORIS |
分类号 |
A61K38/00;A61K31/4178;A61K31/7088;A61K39/00;C07K14/47;C07K14/525;C07K14/715 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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