Methods and compositions for treatment of PTP1B-related diseases

摘要

Cancer, obesity, and diabetes are examples of PTP1B-related diseases. The invention herein provides embodiments of therapeutic methods and compositions for treating PTP1B related diseases by engineering peptides that bind to the functional spine of PTP1B to alter the conformation of the protein and inhibit a function of PTP1B. Molecules bind to amino acid residues of the functional spine of PTP1B, regulate the catalytic cycle, and treat PTP1B-related diseases. For example, molecules bind to at least one of Tyr152, Tyr153, His175, Thr178, Pro185, Phe191, Leu192, Asn193, Cys215, Gly218, Phe280, Val287, Trp291, Lys292, Leu294, Ser295, and Glu297 to reduce at least one symptom of a PTP1B related disease.

主权项

1. A method of treating a subject for a PTP1B related disease, the method comprising the steps of:
administering to a subject a composition that binds to at least one portion of PTP1B protein distal to a catalytic site thereby changing the conformation of enzymatic PTP1B protein; inhibiting at least one function of PTP1B compared to the PTP1B function prior to the administering; and decreasing a symptom of the PTP1B related disease, thereby treating the subject for the disease.