发明名称 STAPLING eIF4E INTERACTING PEPTIDES
摘要 The present invention relates to cross-linked peptides that are associated with human eIF4G and bind to eIF4E, uses thereof and pharmaceutical compositions comprising the peptides.
申请公布号 US2016046672(A1) 申请公布日期 2016.02.18
申请号 US201414778761 申请日期 2014.02.28
申请人 AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH 发明人 Brown Christopher John;Lane David Philip;Quah Soo Tng;Lama Dilraj;Verma Chandra Shekhar
分类号 C07K7/08 主分类号 C07K7/08
代理机构 代理人
主权项 1. An isolated peptide comprising or consisting of the amino acid sequence of:(SEQ ID NO: 21)K1K2R3Y4Xaa1Xaa2Xaa3Xaa4L9L10Xaa5Xaa6Xaa7Xaa8Xaa9 wherein: Xaa1 is selected from the group consisting of S (serine), aminoisobutyric acid and an unnatural amino acid; Xaa2 is selected from the group consisting of R (arginine), aminoisobutyric acid and an unnatural amino acid; Xaa3 is selected from the group consisting of E (glutamic acid), aminoisobutyric acid and an unnatural amino acid; Xaa4 is selected from the group consisting of F (phenylalanine), Q (glutamine), A (alanine), aminoisobutyric acid and an unnatural amino acid; Xaa5 is selected from the group consisting of G (glycine), aminoisobutyric acid and an unnatural amino acid; Xaa6 is selected from the group consisting of F (phenylalanine), L (leucine), aminoisobutyric acid, 2-aminobutyric acid and an unnatural amino acid; Xaa7 is absent or selected from the group consisting of Q (glutamine), aminoisobutyric acid and an unnatural amino acid; Xaa8 is absent or selected from, the group consisting of F (phenylalanine), aminoisobutyric acid and an unnatural amino acid; Xaa9 is absent or selected from the group consisting of aminoisobutyric acid and an unnatural amino acid; wherein the peptide comprises at least one peptide-cross linker linking Xaa1, Xaa2, Xaa3 or Xaa4 with Xaa5, Xaa6, Xaa7, Xaa8 or Xaa9.
地址 Singapore SG
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