Therapeutically active compounds and their methods of use
摘要
Provided are isocitrate dehydrogenase 2 (IDH2) inhibitor compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein. Also provided are polymorphic forms of the IDH2 inhibitor compounds characterized by X Ray powder diffraction patterns, having improved physicochemical properties that influence in vivo dissolution rate for formulation purposes.
申请公布号
AU2014295938(A1)
申请公布日期
2016.02.18
申请号
AU20140295938
申请日期
2014.08.01
申请人
AGIOS PHARMACEUTICALS, INC.
发明人
AGRESTA, SAMUEL V.;GU, CHONG-HUI;SCHENKEIN, DAVID;YANG, HUA;GUO, LITING;TANG, ZHEN;WANG, JIANMING;ZHANG, YANFENG;ZHOU, YAN