发明名称 |
INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF |
摘要 |
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region. In certain embodiments, the disclosure relates to the use of small molecules as microbicides to inhibit HIV-1 infection directly and to sensitize primary HIV-1 to neutralization by readily elicited antibodies. |
申请公布号 |
WO2016025681(A1) |
申请公布日期 |
2016.02.18 |
申请号 |
WO2015US44998 |
申请日期 |
2015.08.13 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
SMITH, AMOS, B. III;SODROSKI, JOSEPH;MADANI, NAVID;MELILLO, BRUNO |
分类号 |
C07C233/06;C07C237/40;C07C279/12 |
主分类号 |
C07C233/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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