A METHOD FOR PRODUCING MICRO PARTICLE FOR BIODEGRADABLE FILLER

摘要

The present invention relates to a method for preparing drug-containing sustained release microparticles, comprising the steps of: (a) dissolving a biodegradable polymer and a drug in a halogenated alkane solvent to form a drug-containing biodegradable polymer solution; (b) homogeneously mixing the drug-containing biodegradable polymer solution in a continuous phase containing a surfactant to form a dispersed phase; (c) maintaining an emulsion including the continuous phase and the dispersed phase at a temperature lower than the boiling point of the halogenated alkane solvent to form microparticles in the continuous phase; (d) primarily drying the microparticles; (e) mixing the primarily dried microparticles with an aqueous alcohol solution, and then maintaining the aqueous alcohol solution at a temperature more than or equal to the boiling point of the halogenated alkane solvent to extract and evaporate the remaining halogenated alkane solvent from the microparticles; and (f) secondarily drying the obtained microparticles for biodegradable filler. The microparticles for biodegradable filler prepared in accordance with the preparation method of the present invention minimize the hydrolysis of the biodegradable polymer in the microparticles, while easily removing the halogenated alkane solvent from the microparticles to inhibit reduction in the molecular weight so as to lower the resorption rate into body when being administered in vivo, thus being utilized effectively in biodegradable skin-care or medical filler.