发明名称 |
BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY |
摘要 |
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof. |
申请公布号 |
EP2406281(B1) |
申请公布日期 |
2016.02.17 |
申请号 |
EP20100713149 |
申请日期 |
2010.03.11 |
申请人 |
HAASE INVESTMENTS UG |
发明人 |
SEEMANN, PETRA;MUNDLOS, STEFAN;REISSNER, CARSTEN;DUDA, GEORG;ZIMMER, JULIA |
分类号 |
C07K14/51;A61K38/18 |
主分类号 |
C07K14/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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