发明名称 |
MULTIPARTICULATE FORM OF ADMINISTRATION, COMPRISING NUCLEIC ACID-CONTAINING MUCOADHESIVE ACTIVE INGREDIENTS, AND METHOD FOR PRODUCING SAID FORM OF ADMINISTRATION |
摘要 |
The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients. |
申请公布号 |
EP1824457(B1) |
申请公布日期 |
2016.02.17 |
申请号 |
EP20050807707 |
申请日期 |
2005.11.05 |
申请人 |
EVONIK RÖHM GMBH |
发明人 |
LIZIO, ROSARIO;PETEREIT, HANS-ULRICH;TRUPTI, DAVE;GOTTSCHALK, MICHAEL |
分类号 |
A61K9/16;A61K31/7088 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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