发明名称 |
IL1RAP EXPRESSION ON ACUTE AND CHRONIC MYELOID LEUKEMIA CELLS |
摘要 |
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and/or inhibiting the growth and/or proliferation of pathological stem cells and/or progenitor cells associated with a neoplastic hematologic disorder, wherein the cells express IL1RAP. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in detecting pathological stem cells and/or progenitor cells associated with a neoplastic hematologic disorder, wherein the cells express IL1RAP. Further provided are pharmacological compositions comprising the agents of the invention and methods of using the same. |
申请公布号 |
EP2985293(A1) |
申请公布日期 |
2016.02.17 |
申请号 |
EP20150187838 |
申请日期 |
2010.08.20 |
申请人 |
CANTARGIA AB |
发明人 |
FIORETOS, THOAS;JÄRÅS, MARCUS |
分类号 |
C07K16/28;A61K38/00;A61P35/02;C07K16/30 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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