| 摘要 |
The present invention relates to a process for the preparation of a compound of formula I
wherein X is -CH 2 -, -CH 2 -CH 2 -, -CH 2 -CH 2 -CH 2 - or -CH 2 -CH 2 -CH 2 -CH 2 -;
Y 1 is -CH 2 - or -CH 2 -CH 2 -; Y 2 is NHR 7 or SH; wherein R 7 is hydrogen, C 1 -C 4 alkyl or phenyl;
R 1 and R 2 , independently from each other, represent aliphatic or aromatic groups;
R 3 and R 4 , independently from each other, represent aliphatic or aromatic groups; R 5 and R 6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ RuCl 2 R 1 €ƒ€ƒ€ƒ€ƒ€ƒ(II)
wherein R 1 is defined as at least one cyclic or non-cyclic molecule containing at least one alkene or alkyne moiety coordinating to the metal in a ·-2 (hapto-2) coordination mode; or R 1 is defined as at least one nitrogen, oxygen or sulfur containing molecule in which the beforementioned atoms coordinate to the metal; in the presence of an inert solvent with a compound of formula III
wherein R 5 , R 6 , Y 1 and Y 2 are as defined under formula I, and a phosphane of formula IV
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 3 R 4 P-X-PR 1 R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(IV)
wherein R 1 , R 2 , R 3 , R 4 and X are as defined under formula I. |
