发明名称 Class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as MRI contrast agents
摘要 The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis. The present invention refers to a new class of derivatives of formula (I), or a pharmaceutically acceptable salt thereof.;
申请公布号 US9259491(B2) 申请公布日期 2016.02.16
申请号 US201314384414 申请日期 2013.03.13
申请人 Bracco Imaging S.P.A. 发明人 Beltrami Lorena;Lattuada Luciano;Maiocchi Alessandro;Visigalli Massimo;Sini Loredana
分类号 C07D243/08;C07F9/645;A61K49/10 主分类号 C07D243/08
代理机构 VIVICAR Law, PLLC 代理人 VIVICAR Law, PLLC
主权项 1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: Y is a group of formula: Y′—NH— or (Y′)2—N—, wherein Y′ is the same or different and is selected from the group consisting of: a linear or branched saturated or unsaturated C1-C20 alkyl group; and a C1-C10 alkyl group interrupted by one or more atoms or groups selected from: —P— and —O—(HO—P═O)—O—, said C1-C10 alkyl group being optionally substituted by one or more groups selected from: hydroxy —OH, carboxy —COOR1, oxycarbonyl-(C1-C30)alkyl and oxycarbonyl-(C2-C30)alkertyl group and wherein R1 is selected from: hydrogen H and a linear or branched C1-C10 alkyl group; L is a bivalent linker selected from: aliphatic C3-C10 cyclic or heterocyclic ring, linear or branched C1-C6 alkyl group and C2-C6 alkenyl or alkynyl group, optionally substituted and optionally interrupted with a group or atom selected from: carbonyl —C═O, thiocarbonyl —C═S, amino —NR1-, carboxy —COO—, oxycarbonyl —OCO—, amido —NR1CO— or —CONR1-, oxygen —O— and sulphur —S—, wherein R1 is as above defined; RI-IV are each independently selected from: hydrogen H, carboxy —COOR1, and —(C1-C6)alkylcarboxy group, wherein R1 is as above defined.
地址 Milan IT