| 发明名称 |
Methods for in vitro maturation of ovarian follicles |
| 摘要 |
The invention relates to methods to be used in the maturation of ovarian follicles and oocytes. More specifically, the invention concerns the use of inhibitors of the phosphatase PTEN, such as oxovanadate and peroxovanadate complexes, in methods for in vitro and in vivo maturation of follicles and oocytes. |
| 申请公布号 |
US9259438(B2) |
申请公布日期 |
2016.02.16 |
| 申请号 |
US200912812930 |
申请日期 |
2009.01.19 |
| 申请人 |
|
发明人 |
Liu Kui |
| 分类号 |
A61K35/54;C12Q1/42;A61K33/24;G01N33/50 |
主分类号 |
A61K35/54 |
| 代理机构 |
Schwegman Lundberg & Woessner, P.A. |
代理人 |
Schwegman Lundberg & Woessner, P.A. |
| 主权项 |
1. A method for the in vitro activation of mammalian non-growing follicles, the method comprising the step of incubating the mammalian follicles in a physiological acceptable medium comprising one or more inhibitors of PTEN, wherein the inhibitor of PTEN is selected from:
Bisperoxo(bipyridine)oxovanadate, Bisperoxo(1,10-phenanthroline)oxovanadate, Bisperoxo(picolinato)oxovanadate, Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate, Di-(picolinate) oxovanadate, Di-(3-hydroxypicolinate) oxovanadate, Bisperoxo(phenylbiguanide)oxovanadate, Di-(phenylbiguanide)oxovanadate, or Bisperoxo(isoquinolinecarboxylic acid)oxovanadate. |
| 地址 |
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