发明名称 |
Biopolymer system for tissue sealing |
摘要 |
A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug. |
申请公布号 |
US9259434(B2) |
申请公布日期 |
2016.02.16 |
申请号 |
US201313942982 |
申请日期 |
2013.07.16 |
申请人 |
Endomedix, Inc. |
发明人 |
Chen Weiliam;Abrahams John M. |
分类号 |
A61K31/722;A61K9/00;A61K38/18;A61K47/48;A61K48/00;A61K49/00;A61K49/04;A61K51/12;A61L24/00;A61L24/04;A61L24/08;A61L24/10;A61K31/721;A61K9/06 |
主分类号 |
A61K31/722 |
代理机构 |
Goodwin Procter LLP |
代理人 |
Goodwin Procter LLP |
主权项 |
1. A biocompatible, biodegradable composition for use in sealing a biological tissue of a living mammal, the composition comprising a hydrogel, the hydrogel being produced by mixing a first solution comprising from about 1% to about 10% by weight of acrylated chitosan with a second solution comprising an oxidized polysaccharide, wherein the mixture, when applied to a biological tissue in need of sealing, forms a hydrogel within a minute after mixing thereby sealing the biological tissue. |
地址 |
Newark NJ US |