Efficacy in treating bacterial infections

摘要

The present disclosure relates to molecules which function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus.

主权项

1. A method of suppressing bacterial infection comprising:
administering ML 141 or its analogs to a patient with Staphylococcus infection, where the analogs are defined by the following structure: where R1 is selected from the group consisting of: hydrogen, hydroxyl, halogen, methoxy, methylenedioxy (—O—CH2—O—), wherein one oxygen of the methylenedioxy (—O—CH2—O—) is bonded to a carbon on a phenyl ring and the other oxygen of the methylenedioxy (—O—CH2—O—) is bonded to an adjacent carbon on the phenyl ring, and polyethylene glycol (—(O—CH2—CH2)n—O-Me) wherein n is any integer; where R2 is selected from the group consisting of: hydrogen, methoxy, and polyethylene glycol (—(O—CH2—CH2)n—O-Me) wherein n is any integer; where R3 is selected from the group consisting of: hydrogen and methyl.