Tumor-targeting gas-generating nanoparticle, method for preparing the same, and tumor-targeting nanoparticle for drug delivery using the same

摘要

A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.

主权项

1. A tumor-targeting gas-generating nanoparticle comprising a polycarbonate core and an amphiphilic coat, the amphiphilic coat being a polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer, a polyethylene oxide-polyglycoliclactic acid copolymer or a polyethylene oxide-polylactic acid copolymer,
wherein the polycarbonate core is poly(cholosteryl γ-butyrolactone-b-propylene oxide) represented by Chemical Formula 1: wherein each of m and n is an integer from 1 to 1000.