| 发明名称 | I-arylpiperazinic ligands of 5-HT7 receptor and use thereof | ||
| 摘要 | The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor and having the following formula IV:;wherein W is O;K, L, M and Q is CH or nitrogen;R1 is hydrogen;R2 is hydrogen; andAr is an aromatic ring with the following formula:;wherein X, Y and Z is CH; and R3 is a five- or six-membered ring selected from the group consisting of:; | ||
| 申请公布号 | US9260400(B2) | 申请公布日期 | 2016.02.16 |
| 申请号 | US201114119860 | 申请日期 | 2011.05.24 |
| 申请人 | UNIVERSITA' DEGLI STUDI DI BARI “ALDO MORO” | 发明人 | Leopoldo Marcello;Lacivita Enza;Colabufo Nicola Antonio;De Giorgio Paola;Berardi Francesco;Perrone Roberto |
| 分类号 | A61K31/496;C07D295/15;C07D295/145;C07D213/56;C07D239/26;C07D401/04;C07D295/096;C07D241/12;C07D295/084;A61K51/04;C07D401/14;C07D403/04;C07D239/34;C07D241/18 | 主分类号 | A61K31/496 |
| 代理机构 | Nixon & Vanderhye PC | 代理人 | Nixon & Vanderhye PC |
| 主权项 | 1. A compound having the following formula IV: wherein W is O; K, L, M and Q is CH or nitrogen; R1 is hydrogen; R2 is hydrogen; and Ar is an aromatic ring with the following formula: wherein X, Y and Z is CH; and R3 is a five- or six-membered ring selected from the group consisting of: | ||
| 地址 | Bari IT | ||