Thermal responsive polymer siloxanes, compositions, and method and applications related thereto

摘要

The invention relates to materials comprising siloxanes, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments.

主权项

1. A composition comprising:
a) a core comprising siloxane moieties; b) at least three polymers grafted to said siloxane moieties to form a plurality of siloxane-polymer conjugates, wherein each of the said at least three polymers comprises at least two reactive functional groups selected from the group consisting of an ester group, an alkenyl group, a hydroxyl group, an amide group, and a carboxylic acid group; c) a crosslinked network formed by linking groups joining two or more of said siloxane-polymer conjugates, wherein
said siloxane moieties are caged structures,said linking groups are selected from the group consisting of alkyl, aryl, polyethylene and urethane groups, andsaid composition has a Tg between 17° C. and 100° C.