Non-electrically conductive hydrogel composition

摘要

Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto. Films prepared from hydrogel compositions containing or entirely composed of the aforementioned continuous hydrophilic phase can be made translucent, and may be prepared using either melt extrusion or solution casting. A preferred use of the hydrogel compositions is in wound dressings, although numerous other uses are possible as well.

主权项

1. A hydrogel composition comprised of a discontinuous hydrophobic phase and a continuous hydrophilic phase, wherein:
(a) the discontinuous hydrophobic phase comprises (i) a butyl rubber, (ii) a plasticizer, (iii) a tackifying resin, and (iv) an optional antioxidant; and (b) the continuous hydrophilic phase comprises (i) a water-swellable cellulosic ester that is insoluble in water at a pH of less than 8.5, (ii) a blend of a poly(N-vinyllactam) and a complementary oligomer capable of hydrogen bonding thereto, where the complementary oligomer is either a polyalkylene glycol or a carboxyl-terminated polyalkylene glycol, and (iii) an optionally added low molecular weight plasticizer, wherein the butyl rubber represents about 5 wt. % to 15 wt. % of the composition, the water-swellable cellulosic ester represents approximately 2 wt. % to approximately 15 wt. % of the composition, the poly(N-vinyllactam) and the complementary oligomer together represent approximately 17.5 wt. % to approximately 45 wt. % of the composition, the low molecular weight plasticizer, when present, represents approximately 2.5 wt. % to approximately 5.0 wt. % of the hydrogel composition, the weight ratio of the poly(N-vinyllactam) to the complementary oligomer is in a range of about 70:30 to about 40:60, and the composition is non-electrically conductive.