Compositions and methods for eye whitening

摘要

The invention provides compositions and methods for whitening of eyes. The provided compositions and methods utilize low concentrations of selective α-2 adrenergic receptor agonists. The compositions preferably include brimonidine.

主权项

1. A method of increasing whiteness of an eye comprising administering to a subject in need thereof a composition comprising from between about 0.001% to about 0.05% weight by volume of a selective α-2 adrenergic receptor agonist selected from lofexidine, apraclonidine, mivazerol, clonidine, brimonidine, alpha methyl dopa, guanfacine, dexmedetomidine, (+)-(S)-4-[1-(2,3-dimethyl-phenyl)-ethyl]-1,3-dihydro-imidazole-2-thione, and 1-[(imidazolidin-2-yl)imino]indazole, or a pharmaceutically acceptable salt thereof.